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610

抑制剂 & 化合物

45

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T24797	SK609 HCl SK-609 HCl,SK609 hydrochloride,SK 609 HCl,SK 609 hydrochloride,SK-609 hydrochloride
	SK609 HCl is a selective dopamine D3 receptor agonist. It also has atypical signaling properties.
T12928	SK33	Androgen Receptor	Endocrinology/Hormones
	SK33 是一种有效的组织选择性抗雄激素药物，是一种肌醇类似物，能够降低雄激素受体 (AR) 的转录活性。
T34650	SK&F 107461 SK&F107461,SK&F-107461
	F 107461 is a hydroxyethylene dipeptide isostere.
T24798	SK-7041 SK 7041
	SK-7041 is an effective HDAC inhibitor that acts by preferentially inhibiting class I HDAC1 and HDAC2.
T26191	SK&F 104976 SK&F104976,Skf104976,Skf 104976,SK&F-104976,Skf-104976
	SK&F 104976 is a 32-carboxylic acid derivative of lanosterol. It was found to be a potent lanosterol 14 alpha-demethylase (14 alpha DM) inhibitor.
T7524	Metiamide 甲硫米特,SK&F 92058	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Metiamide (SK&F 92058) 是一种组胺H2受体拮抗剂。
T29067	Upacicalcet PLS-240,SK-1403,AJT-240	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Upacicalcet (AJT-240) 是一种静脉内拟钙剂，是一种可用于人血液透析的 SHPT，通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌，从而降低血液中的 PTH 水平。 3 Upacicalcet 是钙敏感受体的正变构调节剂，可预防大鼠腺嘌呤诱导的继发性甲状旁腺功能亢进模型中的血管钙化和骨骼疾病。
T26644	Apomine SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A	HMG-CoA Reductase	Metabolism
	Apomine (SR-9223i) 是一种 HMG-CoA-还原酶抑制剂，可在体外促进骨髓瘤细胞的凋亡，并与体内骨髓瘤的调节有关。 Apomine 加速 3-羟基-3-甲基戊二酰-CoA 还原酶的降解并刺激低密度脂蛋白受体活性。 Apomine 通过下调 3-羟基-3-甲基戊二酰-CoA 还原酶来增强洛伐他汀对骨髓瘤细胞的抗肿瘤作用。
T7133	Anagliptin SK-0403,阿拉格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Anagliptin (SK-0403) 是一种选择性的二肽酰肽酶 4 抑制剂，IC50=3.8 nM，对 DPP-8/9 的选择性相对较弱，IC50分别为 68 和 60 nM。
T34651	SK&F 108361 Skf-108361,SK&F-108361,Skf 108361,SK&F108361,Skf108361
	SK&F 108361 is a symmetric diol that binds HIV-1 protease symmetrically.
T69596	SK-575
	SK-575 is a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations. SK-575 achieves durable tumor growth inhibition in mice when used as a single agent or in combination with cytotoxic agents, such as temozolomide and cisplatin.
T20641	Propagermanium Dipropanoic acid germanium sequioxide,SK-818,Ge 132,二羧乙基三氧化二锗,Ge132,SK 818,Ge-132	Others	Others
	Propagermanium (Ge132) 是一种锗的有机金属化合物，在日本已被用作治疗慢性乙型肝炎的药物。
T34652	SK&F 39728-A SK&F39728-A,SK&F 1-39728,SK&F-39728-A,Skf 39728-A
	SK&F 39728-A is a bioactive chemical.
T24795	SK&F 103784 Skf 103784,Skf-103784,Skf103784
	SK&F 103784 is a vasopressin antagonist.
TQ0126	Mirodenafil dihydrochloride SK-3530 dihydrochloride,米罗那非二盐酸盐	PDE	Metabolism
	Mirodenafil dihydrochloride 是一种磷酸二酯酶5（PDE-5）抑制剂，可作用于勃起功能紊乱的研究。
T28787	SK&F-95601 SK&F 95601,SKF95601,SKF 95601,SKF-95601
	F-95601 is a proton pump inhibitor.
T26190	SK&F 106760 SK&,F-106760,SKF 106760,SKF-106760,F106760,SKF106760,F 106760
	SKF 106760 is used as a glycoprotein IIb/IIIa antagonist.
T41273	Phen Green SK diacetate

T28788	SK-216 SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor
	SK-216 is a specific PAI-1 inhibitor. SK-216 reduced the extent of angiogenesis in the tumors and inhibited VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro. SK-216 reduced the degree of bleomycin-induced pulmon
T24796	SK&F 107260 Skf107260,Skf-107260,Skf 107260
	SK&F 107260 is an RGD-containing peptide. It is a potent GP IIb/IIIa antagonist and a vitronectin antagonist.
T23761	Atiprimod dimaleate SK&F-106615,SK&F 106615,SK&F106615
	Atiprimod Dimaleate is a JAK2 inhibitor.
T35203	Xylonidine SK&F-35866,SK&F35866,SK&F 35866
	Xylonidine is a biochemical.
T70618	SK609
	SK609 is a selective dopamine D3 receptor agonist which significantly improves the performance of the impaired paw and normalizes the bilateral asymmetry associated with the hemiparkinson rat.
T70283	SK 946
	SK 946 is a cognition activator.
T28796	SKI2852 SK I2852,SKI-2852
	SKI2852 is a highly Potent, selective, and orally bioavailable inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). hHSD1 IC50 = 2.9nM; mHSD1 IC50 = 1.6nM.
T33740	NSC 157449 SK&F-83589,SK&F 83589,NSC157449,NSC-157449
	NSC 157449 is a bioactive chemical.
T23883	Chlorasquin Ccnsc-529,861,Ccnsc 529,861,SK 29861,Ccnsc529,861,SK-29861
	Chlorasquin is a dihydrofolate reductase inhibitor.
T74558	SK-575-NEG
	SK-575-NEG（化合物28）是SK-575的甲基化对应物，通过对SK-575中的哌啶-2,6-二酮氨基进行甲基化合成而得，用作对照化合物。SK-575-NEG强效结合PARP1，IC50值仅为2.64 nM。在1 μM浓度下，SK-575-NEG对MDA-MB-436和Capan-1细胞中PARP1的降解完全无效。
T81151	SK-MLCK M13
	SK-MLCK M13，作为具生物活性的肽类化合物，代表着钙调蛋白（CaM）靶标蛋白的CAM结合域，其中CaM为广泛存在的Ca2+结合蛋白。
T16079	Mirodenafil 米罗那非,SK3530	PDE	Metabolism
	Mirodenafil 是一种磷酸二酯酶5（PDE-5）抑制剂，可用于勃起功能紊乱的研究。
T25453	Glaspimod F 107647,SK&,F-107647,F107647
	Glaspimod is a synthetic hematoregulatory peptide. It shares biological and/or modulatory activities with natural hematopoetic cytokines.
T33787	Olaflur SKF 38095,GA 297,SK&F 38095
	Olaflur is a compound that prevents dental caries.
T31364	Dehydelone KOS1584,SK-10088,KOS-1584,R-1645,SK10088,R1645
	Dehydelone(KOS-1584, R-1645, SK-10088) is a microtubule stabilizer that may be used in the treatment of non-small cell lung cancer.
T32834	Lobendazole SK&F 24529,SKF 24529,NSC-42044,NSC42044,NSC 42044
	Lobendazole is a metabolite of thiophanate.
T28794	SKF-97574 HCl SKF97574,SKF-97574,B-9937-051,BY 574,SKF 97574,SK&F-97574
	SKF-97574 is proton pump inhibitor.
T68818	Icotidine
	Icotidine is an antagonist of histamine at both H1 and H2 receptors.
T34653	SK1071
	SK1071 is a novel migrastatin analogs, which demonstrated improved performance over migrastatin, with nanomolar IC50 values in chamber cell migration assays with tumor cells and human umbilical vein endothelial cells (HUVECs), and in wound healing assays.
T9033	BTYNB MDK6620,BTYNB IMP1 Inhibitor	Others; c-Myc; NF-κB	Cell Cycle/Checkpoint; NF-κB; Others
	BTYNB (MDK6620) 是IMP1结合 c-Myc mRNA 的有效选择性抑制剂，IC50为 5 μM。它下调 β-TrCP1 mRNA 并减少NF-κB 的激活。它通过损害 IGF2 mRNA 结合蛋白 1 结合来破坏这种增强子功能，可用于癌症研究。
T71174	PBT434 HBr
	PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is g...
T70282	Drofenine
	Drofenin is an anticonvulsant. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers (neurotropic musculotropic effect). Drofenin also acts as FIASMA (functional inhibitor of acid sphingomyelinase )
T9522	Rimtuzalcap CAD-1883	Potassium Channel	Membrane transporter/Ion channel
	Rimtuzalcap (CAD-1883) 是首创的，选择性的小电导钙激活钾通道 (SK 通道) 正变构调节剂。Rimtuzalcap 可用于运动障碍的研究，包括脊髓小脑性共济失调 (SCA)和特发性震颤 (ET)。
T70616	ACT-672125
	ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner.
T68587	Oxmetidine mesylate
	Oxmetidine mesylate is an antagonist to Histamine H2 Receptors
T12927	SK1-IN-1	S1P Receptor	GPCR/G Protein
	SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
T70252	RU1968 bis-TFA salt
	RU1968 bis-TFA salt is an inhibitor of the sperm-specific Ca2+ channel CatSper, thereby inhibiting human Slo3 with about 15-fold lower potency than CatSper.
T60798	SK1- I hydrochloride
	SK1-I hydrochloride (BML-258 hydrochloride) 是鞘氨醇类似物，能够增强细胞自噬并显示抗癌活性。SK1-I hydrochloride 是同工酶特异性SPHK1竞争抑制剂 (Ki = 10 μM)。
T61605	SK3 Channel-IN-1
	SK3 Channel-IN-1 (compound 7a) is a powerful and selective modulator of the SK3 channel. It demonstrates significant efficacy in inhibiting breast cancer MDA-MB-435 cell migration while maintaining low cytotoxicity in other cell lines. Furthermore, SK3 Channel-IN-1 exhibits the ability to modulate ion channel activity in cancer cells [1].
T30485	SK1-I BML 258,BML-258,BML258,BML-258 HCl
	BML-258 HCl was removed and discontinued.
T8461	SKI V	Apoptosis; PI3K; S1P Receptor	Apoptosis; GPCR/G Protein; PI3K/Akt/mTOR signaling
	SKI V 是一种非竞争性非脂质鞘氨醇激酶抑制剂，对 GST-hSK 的IC50为 2 μM。它减少有丝分裂的第二信使鞘氨醇-1-磷酸的形成，可诱导细胞凋亡并具有抗肿瘤活性。它还抑制PI3K，对 hPI3k 的IC50为 6 μM。
T6673	SKI II SphK-I2	Apoptosis; Wnt/beta-catenin; S1P Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells
	SKI II (SphK-I2) 是一种口服有效的合成鞘氨醇激酶 (SK)抑制剂，抑制 SK1 和 SK2，IC50值分别为 78 μM 和 45 μM。它通过诱导溶酶体/蛋白酶体降解，不可逆地抑制SK1。

化合物

Cat.No: T24797

Synonym: SK-609 HCl,SK609 hydrochloride,SK 609 HCl,SK 609 hydrochloride,SK-609 hydrochloride

Cat.No: T12928

Target: Androgen Receptor

Cat.No: T34650

Synonym: SK&F107461,SK&F-107461

Cat.No: T24798

Synonym: SK 7041

Cat.No: T26191

Synonym: SK&F104976,Skf104976,Skf 104976,SK&F-104976,Skf-104976

Cat.No: T7524

Synonym: 甲硫米特,SK&F 92058

Target: Histamine Receptor

Cat.No: T29067

Synonym: PLS-240,SK-1403,AJT-240

Target: Calcium Channel

Cat.No: T26644

Synonym: SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A

Target: HMG-CoA Reductase

Cat.No: T7133

Synonym: SK-0403,阿拉格列汀

Target: Proteasome, DPP-4

Cat.No: T34651

Synonym: Skf-108361,SK&F-108361,Skf 108361,SK&F108361,Skf108361

Cat.No: T69596

Cat.No: T20641

Synonym: Dipropanoic acid germanium sequioxide,SK-818,Ge 132,二羧乙基三氧化二锗,Ge132,SK 818,Ge-132

Target: Others

Cat.No: T34652

Synonym: SK&F39728-A,SK&F 1-39728,SK&F-39728-A,Skf 39728-A

Cat.No: T24795

Synonym: Skf 103784,Skf-103784,Skf103784

Mirodenafil dihydrochloride

Cat.No: TQ0126

Synonym: SK-3530 dihydrochloride,米罗那非二盐酸盐

Target: PDE

Cat.No: T28787

Synonym: SK&F 95601,SKF95601,SKF 95601,SKF-95601

Cat.No: T26190

Synonym: SK&,F-106760,SKF 106760,SKF-106760,F106760,SKF106760,F 106760

Phen Green SK diacetate

Cat.No: T41273

Cat.No: T28788

Synonym: SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Cat.No: T24796

Synonym: Skf107260,Skf-107260,Skf 107260

Atiprimod dimaleate

Cat.No: T23761

Synonym: SK&F-106615,SK&F 106615,SK&F106615

Cat.No: T35203

Synonym: SK&F-35866,SK&F35866,SK&F 35866

Cat.No: T70618

Cat.No: T70283

Cat.No: T28796

Synonym: SK I2852,SKI-2852

Cat.No: T33740

Synonym: SK&F-83589,SK&F 83589,NSC157449,NSC-157449

Cat.No: T23883

Synonym: Ccnsc-529,861,Ccnsc 529,861,SK 29861,Ccnsc529,861,SK-29861

Cat.No: T74558

Cat.No: T81151

Cat.No: T16079

Synonym: 米罗那非,SK3530

Target: PDE

Cat.No: T25453

Synonym: F 107647,SK&,F-107647,F107647

Cat.No: T33787

Synonym: SKF 38095,GA 297,SK&F 38095

Cat.No: T31364

Synonym: KOS1584,SK-10088,KOS-1584,R-1645,SK10088,R1645

Cat.No: T32834

Synonym: SK&F 24529,SKF 24529,NSC-42044,NSC42044,NSC 42044

Cat.No: T28794

Synonym: SKF97574,SKF-97574,B-9937-051,BY 574,SKF 97574,SK&F-97574

Cat.No: T68818

Cat.No: T34653

Cat.No: T9033

Synonym: MDK6620,BTYNB IMP1 Inhibitor

Target: Others, c-Myc, NF-κB

Cat.No: T71174

Cat.No: T70282

Cat.No: T9522

Synonym: CAD-1883

Target: Potassium Channel

Cat.No: T70616

Oxmetidine mesylate

Cat.No: T68587

Cat.No: T12927

Target: S1P Receptor

RU1968 bis-TFA salt

Cat.No: T70252

SK1- I hydrochloride

Cat.No: T60798

SK3 Channel-IN-1

Cat.No: T61605

Cat.No: T30485

Synonym: BML 258,BML-258,BML258,BML-258 HCl

Cat.No: T8461

Target: Apoptosis, PI3K, S1P Receptor

Cat.No: T6673

Synonym: SphK-I2

Target: Apoptosis, Wnt/beta-catenin, S1P Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T2218	8-Azaguanine Azaguanine-8,SK 1150,8-氮鸟嘌呤,NSC-749,SF-337	Nucleoside Antimetabolite/Analog; Others; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	8-Azaguanine (SK 1150) 是一种具有潜在抗肿瘤活性的嘌呤类似物。它易于掺入核糖核酸中，干扰正常的生物合成途径，从而抑制细胞生长，可作为抗代谢药。
T75634	Demycarosyl-3D-β-D-digitoxosylmithramycin SK
	Demycarosyl-3D-β-D-digitoxosylmithramycin SK 为Mithramycin类似物，展现出显著的抗肿瘤活性。该化合物通过与DNA结合蛋白结合并抑制其功能，有效阻断肿瘤细胞的增殖与生长。
T3869	Skimmin 茵芋苷,Skimmine	Others	Others
	Skimmin (Skimmine) 是一种香豆素类物质。存在于圆锥绣球中，能够抑制免疫复合物的沉积，具有抗炎作用。
T2939	Forskolin 毛喉素,Coleonol,Colforsin	FXR; Adenylyl cyclase; AChR; Autophagy	Autophagy; Metabolism; Neuroscience
	Forskolin (Coleonol) 属于天然产物，是一种腺苷酸环化酶激活剂 (EC50=0.5 μM)。Forskolin 可以增加 cAMP 水平，可以激活 PXR 和 FXR，也可以诱导细胞自噬。Forskolin 对心脏产生正性肌力作用，具有血小板抗凝集和降压作用。
TN1520	Isoforskolin Coleonol B	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Isoforskolin 源自毛喉鞘蕊花，可减少人单核白细胞中 TNF-α、IL-1β、IL-6 和 IL-8 的分泌。Isoforskolin 可用于治疗莱姆关节炎的研究。
TN1040	Skullcapflavone II	COX; Antibacterial; TGF-beta/Smad	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Stem Cells
	Skullcapflavone II 是从黄芩中提取的黄酮，具有抗炎作用。它对 M. aurum 和 M. bovisBCG 具有较强的抗菌活性。它还调节破骨细胞的分化、存活和功能。
T5654	Musk ketone	Others	Others
	Musk ketone 可诱导癌细胞生长抑制和凋亡。它增加谷胱甘肽 S-转移酶的活性，因此可能被证明是有用的癌症化学保护剂。
T2S2109	Skimmianine beta-Fagarine,Skimmianin,茵芋碱,Chloroxylonine,Skimmiamine	Others	Others
	Skimmianine (Chloroxylonine) 是一种呋喹啉类生物碱，主要存在于芸香科，具有抗炎、抗痉挛和抗血小板聚集活性。它对多种癌细胞系具有细胞毒性和基因毒性。
T5281	Skatole 粪臭素,Scatole,3-Methylindole,3-Methylindole,3-甲基吲哚,3-Methyl-1H-indole,beta-Methylindole	AhR; p38 MAPK; Aryl Hydrocarbon Receptor; Endogenous Metabolite; Antibacterial; Autophagy; Antifungal	Autophagy; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology
	Skatole (3-Methyl-1H-indole) 是由肠道菌群产生的，通过激活芳基烃受体和 p38调节肠上皮细胞功能。
TN2112	Przewalskinic acid A	Others	Others
	Przewalskinic acid A is a rare, water-soluble, and highly biologically active ingredient found, thus far, only in the Salvia przewalskii Maxim herb.
TN4827	Preskimmianine	Others	Others
	Preskimmianine is the biogenetic precursor of skimmianine.It can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells.
TN6197	8,8''-Biskoenigine
	8,8''-Biskoenigine 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6197，CAS号为 477890-82-7。
TN4835	Przewalskin	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Przewalskin A and Przewalskin B showed modest anti-HIV-1 activity with EC50 = 41 and 30 microg/mL, respectively.
TN1001	Apiosylskimmin	Others	Others
	Apiosylskimmin is a natural product from Angelica gigas.
T16160	Musk tibetene Musk tibetine	Others	Others
	Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell lines. Musk tibetene is a nitro musk compound with carcinogenic activity.
T75545	PCSK9-IN-9
	PCSK9-IN-9 是一种天然来源的异香豆素。PCSK9-IN-9 可抑制原蛋白转化酶枯草菌素 kexin 型 9 (PCSK9)、IDOL 和 SREBP2的 mRNA 表达水平。PCSK9-IN-9 抑制 PCSK9的 IC50为 11.9 μM。
TN4073	Forskolin G	Others	Others
	Forskolin is known to elevate intracellular cAMP levels.
TN5019	Siegeskaurolic acid	TNF; NOS; NF-κB; COX; NO Synthase; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience; NF-κB
	Siegeskaurolic acid 是一种具有抗炎活性的天然产物。
TN4074	Forskolin J	Others	Others
	Forskolin J 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4074，CAS号为 81873-08-7。
TN5033	Skullcapflavone I	IL Receptor; Caspase; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se
T3S1589	Notoginsenoside Fa	Others	Others
	Notoginsenoside Fa 是一种原人参二醇型皂苷，从P. notoginseng 提取出来得到，有激活和恢复退化脑功能的潜能。
TN2256	Taccalonolide B 根薯酮内酯B,根薯酮内酯 B	Microtubule Associated	Cytoskeletal Signaling
	Taccalonolide B 是从广西裂果薯中分离得到的一种微管稳定剂，具有抗肿瘤活性。它抑制 SK-OV-3 细胞的生长，IC50 为 208 nM，在体外对过表达 P-糖蛋白 (Pgp) 和多药耐药蛋白 (MRP7) 的细胞系有效。
TN1516	Cnidicin 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮	NOS; NO Synthase	Immunology/Inflammation
	Cnidicin 是一种香豆素，对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。
TN2097	Pomolic acid 坡模酸	Apoptosis; Caspase; HIV Protease; AMPK	Apoptosis; Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Pomolic acid 是从野鸦椿中分离出来的一种五环三萜烯。它抑制肿瘤细胞的生长，诱导细胞凋亡，有用于前列腺癌的潜力。
TN2254	Taccalonolide A 根薯酮内酯A,根薯酮内酯 A	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Taccalonolide A 是从水田七根茎中分离得到的一种类固醇，具有细胞毒性和抗疟活性。它在体外对过表达 p 糖蛋白、多药耐药蛋白 7 细胞系有抑制作用，抑制 SK-OV-3 细胞生长的 IC50值为 622 nM。它是微管稳定剂，能引起 G2-M 期滞留、Bcl-2 磷酸化，并引发细胞凋亡。
T2850	Bicuculline 荷包牡丹碱,(+)-Bicuculline,d-Bicuculline	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Bicuculline ((+)-Bicuculline) 是从东北延胡索中提取的一种生物碱，能阻断 Ca2+激活钾 (SK) 通道。它是一种竞争性的神经递质 GABAA 受体拮抗剂，IC50为 2 μM。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
T3932	Viscidulin I	Others	Others
	Viscidulin I 存在于黄芩中，是一种天然产物。
TN2666	1alpha-Hydroxytorilin	Others	Others
	1alpha-Hydroxytorilin exhibits cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
TN4959	Schizandriside	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysaccharide-stimulated RAW 264.7 cells. It shows significant cytotoxicity against A549, SK-OV-3, SK
TN4373	Kaempferol tetraacetate	Antifection	Microbiology/Virology
	Kaempferol tetraacetate is a potent antiplatelet agent. It exhibits significant cytotoxicity in vitro against three human cell lines HL-60, U937 and SK-MEL-1.
TN3832	Deoxyflindissone	Others	Others
	Deoxyflindissone exhibits significant cytotoxic activity against the A549, SK-OV-3, SK-MEL-2, and XF498 cell lines.
TN2669	1beta-Hydroxytorilin	Others	Others
	1beta-Hydroxytorilin exhibits cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
T82298	Glucozaluzanin C
	Glucozaluzanin C，一种木脂素类化合物，由菊科鸢尾根的MeOH提取物中分离得到，显示出对多种细胞系具有显著的生物活性。具体而言，其在A549、SK-OV-3、SK-MEL-2、XF498和HCT15细胞上的ED50值依次为2.45 μg/mL、1.37 μg/mL、0.40 μg/mL、1.41 μg/mL、1.43 μg/mL。
TN6014	Norcepharadione B 鱼腥草
	Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3,
TN4146	Glutinol acetate	TNF	Apoptosis
	Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also has anti-inflammatory effect, exhibits moderate inhibitory activity of TNF-alpha secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line.
TN3007	4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan	Others	Others
	4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan shows cytotoxic activities against four tumor cell lines (A549, SK-OV-3, SKMEL-2 and HCT15).
TN3862	Dihydroprehelminthosporol	Others	Others
	Dihydroprehelminthosporol is a strongly phytotoxic metabolite, it exhibits cytotoxicity towards two human cancer cell lines, A549 and SK-OA-3.
T37543	Anhydroepiophiobolin A
	Anhydroepiophiobolin A is a sesterterpenoid fungal metabolite that has been found in B. oryzae. It is cytotoxic to HepG2 and K562 cells (IC50s = 47.1 and 35.6 μM, respectively) as well as A549, SKOV3, SK-MEL-2, XF498, and HCT15 cells (IC50s = 1.6-1.9 μg/ml). Anhydroepiophiobolin A is phytotoxic to S. viridis and D. erucoides in a leaf puncture assay.
T83597	(+)-Menthyl acetate
	(+)-Menthyl acetate是一种从Cunila angustifolia Benth精油中分离得到的化学化合物。它对MCF-7细胞株具有较高的选择性，其半抑制浓度（IC50）为34.0 μg/mL，而对SK-Mel-28细胞株的选择性较低，IC50为279.9 μg/mL，并且对A549细胞没有致死作用。
T35483	19,20-Epoxycytochalasin D
	19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 &#181M, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 &#181M.
TN2977	3-O-trans-p-Coumaroyltormentic acid	Caspase; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, an...
T37452	Stephacidin B
	Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc...
T36749	Herboxidiene
	Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo...
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Cat.No: T2218

Synonym: Azaguanine-8,SK 1150,8-氮鸟嘌呤,NSC-749,SF-337

Target: Nucleoside Antimetabolite/Analog, Others, Endogenous Metabolite

Demycarosyl-3D-β-D-digitoxosylmithramycin SK

Cat.No: T75634

Cat.No: T3869

Synonym: 茵芋苷,Skimmine

Target: Others

Cat.No: T2939

Synonym: 毛喉素,Coleonol,Colforsin

Target: FXR, Adenylyl cyclase, AChR, Autophagy

Cat.No: TN1520

Synonym: Coleonol B

Target: IL Receptor, TNF

Skullcapflavone II

Cat.No: TN1040

Target: COX, Antibacterial, TGF-beta/Smad

Cat.No: T5654

Target: Others

Cat.No: T2S2109

Synonym: beta-Fagarine,Skimmianin,茵芋碱,Chloroxylonine,Skimmiamine

Target: Others

Cat.No: T5281

Synonym: 粪臭素,Scatole,3-Methylindole,3-Methylindole,3-甲基吲哚,3-Methyl-1H-indole,beta-Methylindole

Target: AhR, p38 MAPK, Aryl Hydrocarbon Receptor, Endogenous Metabolite, Antibacterial, Autophagy, Antifungal

Przewalskinic acid A

Cat.No: TN2112

Target: Others

Cat.No: TN4827

Target: Others

8,8''-Biskoenigine

Cat.No: TN6197

Cat.No: TN4835

Target: HIV Protease

Cat.No: TN1001

Target: Others

Cat.No: T16160

Synonym: Musk tibetine

Target: Others

Cat.No: T75545

Cat.No: TN4073

Target: Others

Siegeskaurolic acid

Cat.No: TN5019

Target: TNF, NOS, NF-κB, COX, NO Synthase, Prostaglandin Receptor

Cat.No: TN4074

Target: Others

Skullcapflavone I

Cat.No: TN5033

Target: IL Receptor, Caspase, Prostaglandin Receptor

Notoginsenoside Fa

Cat.No: T3S1589

Target: Others

Taccalonolide B

Cat.No: TN2256

Synonym: 根薯酮内酯B,根薯酮内酯 B

Target: Microtubule Associated

Cat.No: TN1516

Synonym: 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮

Target: NOS, NO Synthase

Cat.No: TN2097

Synonym: 坡模酸

Target: Apoptosis, Caspase, HIV Protease, AMPK

Taccalonolide A

Cat.No: TN2254

Synonym: 根薯酮内酯A,根薯酮内酯 A

Target: Apoptosis, Microtubule Associated

Cat.No: T2850

Synonym: 荷包牡丹碱,(+)-Bicuculline,d-Bicuculline

Target: GABA Receptor

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: T3932

Target: Others

1alpha-Hydroxytorilin

Cat.No: TN2666

Target: Others

Cat.No: TN4959

Target: Prostaglandin Receptor

Kaempferol tetraacetate

Cat.No: TN4373

Target: Antifection

Deoxyflindissone

Cat.No: TN3832

Target: Others

1beta-Hydroxytorilin

Cat.No: TN2669

Target: Others

Glucozaluzanin C

Cat.No: T82298

Norcepharadione B

Cat.No: TN6014

Synonym: 鱼腥草

Glutinol acetate

Cat.No: TN4146

Target: TNF

4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan

Cat.No: TN3007

Target: Others

Dihydroprehelminthosporol

Cat.No: TN3862

Target: Others

Anhydroepiophiobolin A

Cat.No: T37543

(+)-Menthyl acetate

Cat.No: T83597

19,20-Epoxycytochalasin D

Cat.No: T35483

3-O-trans-p-Coumaroyltormentic acid

Cat.No: TN2977

Target: Caspase, Antifection

Cat.No: T37452

Cat.No: T36749

Cat.No: T36954

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